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FDA Shortage Check

Is Methotrexate Sodium Injection in shortage?

Label: plusbeauxjours · shortage label · not a prescription, not a pharmacy, not FDA

IN SHORTAGE

Methotrexate Sodium Injection: in shortage

Injections (vials)
A generic injection, not your medicine. We draw dosage forms, not products, and never pills you could match to yours.
  • Reason: “Demand increase for the drug”. FDA shortage reason (FDASIA), reported by the manufacturer
  • Reason: “Other”. FDA shortage reason (FDASIA), reported by the manufacturer
  • Estimate: “Estimated recovery: Jan 2027”. Manufacturer’s estimate, Accord Healthcare Inc., Oct 17, 2026
DRUG
Methotrexate Sodium Injection
FDA LISTING
FORM
injection
STATUS
Currently in Shortage
FIRST POSTED
Mar 13, 2023
LAST FDA UPDATE
Oct 21, 2026
AS OF
Oct 24, 2026
SOURCE

FDA lists 14 presentations: 4 unavailable · 2 limited · 8 available.

FDA Drug Shortages checked Oct 24, 2026, 21:05 ET · FDA updates daily · manufacturer-reported

Information from FDA’s drug shortage list, reported by manufacturers. Not medical advice. Don’t stop, change or ration a medicine without talking to your prescriber or pharmacist.

FDA's listing, word for word: Methotrexate Sodium Injection. 14 presentations from 5 makers.

Check your own medication, form and strength

What to ask at the counter

  1. Is this a supply problem at this pharmacy, or everywhere? Could another pharmacy have it? FDA consumer FAQ (opens in a new tab)
  2. Is my strength or the maker you stock affected? FDA list, by presentation
  3. Is there an alternative to this medicine I should ask my prescriber about? FDA consumer FAQ (opens in a new tab)
  4. When should I check back, or can you order it?

FDA: “talk with your health care provider or pharmacist for other treatment options during the shortage.” FDA Drug Shortages page (opens in a new tab)

This listing on FDA ↗ (opens in a new tab)Report a shortage to FDA: drugshortages@fda.hhs.gov

Every presentation FDA lists, by maker

Availability is FDA's text for each package, as the manufacturer reported it. Makers with unavailable or limited packages come first.

Accord Healthcare Inc.2 presentations · 1 unavailable · 1 available or not stated

Contact (FDA's listing): 866-941-7875, option 2

  • 25 mg/1 mL

    Methotrexate Sodium Preservative Free, Injection, 25 mg/1 mL (NDC 16729-277-35)

    Short dated inventory with expiry of 8/31/2027 available; Estimated recovery: Jan 2027

    NDC 16729-277-35Reverified

    Unavailable

  • 25 mg/1 mL

    Methotrexate Sodium Preservative Free, Injection, 25 mg/1 mL (NDC 16729-277-30)

    NDC 16729-277-30Revised

    Available

Hikma Pharmaceuticals USA, Inc.2 presentations · 2 unavailable

Contact (FDA's listing): 800-631-2174

  • 1 g

    Methotrexate, Preservative Free, Injection, 1 g (NDC 0143-9830-01)

    Additional lots will be available in the November 2026 timeframe. Short Dated Prodcut Available.

    NDC 0143-9830-01Revised

    Unavailable

  • 25 mg/1 mL

    Methotrexate, Preservative Free, Injection, 25 mg/1 mL (NDC 0143-9519-10)

    Additional lots will be available in the October 2026 timeframe. Product will be made available as it is released.

    NDC 0143-9519-10Reverified

    Unavailable

Teva Pharmaceuticals USA, Inc.3 presentations · 1 unavailable · 2 limited

Contact (FDA's listing): 800-545-8800

  • 25 mg/1 mL

    Methotrexate Sodium Preservative Free, Injection, 25 mg/1 mL (NDC 0703-3675-01)

    Estimated Recovery: Novemeber 2026

    NDC 0703-3675-01Revised

    Unavailable

  • 25 mg/1 mL

    Methotrexate Sodium Preservative Free, Injection, 25 mg/1 mL (NDC 0703-3671-01)

    Estimated recovery: October 2026

    NDC 0703-3671-01Reverified

    Limited Availability

  • 25 mg/1 mL

    Methotrexate Sodium Preservative Free, Injection, 25 mg/1 mL (NDC 0703-3678-01)

    Estimated recovery: October 2026

    NDC 0703-3678-01Reverified

    Limited Availability

Fresenius Kabi USA, LLC2 presentations · 2 available or not stated

Contact (FDA's listing): 888-386-1300

  • 1 g

    Methotrexate Preservative Free, Injection, 1 g (NDC 63323-122-50)

    Check wholesaler for inventory

    NDC 63323-122-50Reverified

    Available

  • 25 mg/1 mL

    Methotrexate Sodium, Injection, 25 mg/1 mL (NDC 63323-123-10)

    Check wholesaler for inventory

    NDC 63323-123-10Reverified

    Available

Hospira, Inc., a Pfizer Company5 presentations · 5 available or not stated

Contact (FDA's listing): 844-646-4398

  • 1 g/40 mL (25 mg/mL)

    Methotrexate Sodium, Injection, 1 g/40 mL (25 mg/mL) (NDC 61703-124-40)

    NDC 61703-124-40Reverified

    Available

  • 1 g/40 mL (25 mg/mL)

    Methotrexate Sodium, Injection, 1 g/40 mL (25 mg/mL) (NDC 61703-408-25)

    NDC 61703-408-25Reverified

    Available

  • 1 g/40 mL (25 mg/mL)

    Methotrexate Sodium, Injection, 1 g/40 mL (25 mg/mL) (NDC 61703-408-41)

    NDC 61703-408-41Reverified

    Available

  • 50 mg/2 mL (25 mg/mL)

    Methotrexate Sodium, Injection, 50 mg/2 mL (25 mg/mL) (NDC 61703-350-10)

    NDC 61703-350-10Reverified

    Available

  • 50 mg/2 mL (25 mg/mL)

    Methotrexate Sodium, Injection, 50 mg/2 mL (25 mg/mL) (NDC 61703-350-38)

    NDC 61703-350-38Reverified

    Available

What the manufacturers told FDA

  • Accord Healthcare Inc. · ‘Short dated inventory with expiry of 8/31/2027 available; Estimated recovery: Jan 2027’ · updated Oct 2026
  • Teva Pharmaceuticals USA, Inc. · ‘Estimated Recovery: Novemeber 2026’ · updated Oct 2026
  • Teva Pharmaceuticals USA, Inc. · ‘Estimated recovery: October 2026’ · updated Oct 2026

More on FDA ↗ (opens in a new tab)

Reason for the shortage (FDASIA)

  • Demand increase for the drug
  • Other

As reported by the manufacturer under the Food and Drug Administration Safety and Innovation Act.

Alternatives

FDA lists none: “Providing a list of alternative drug products for a drug in shortage is part of the ‘practice of medicine.’ FDA does not regulate the practice of medicine.” Your prescriber or pharmacist can talk through options with you. ASHP also tracks shortages and suggested alternatives (different criteria) ↗ (opens in a new tab)

Questions

Is Methotrexate Sodium Injection in shortage?
Yes. As of Oct 24, 2026, FDA lists Methotrexate Sodium Injection as currently in shortage: 14 presentations, 4 unavailable and 2 limited.
When will the Methotrexate Sodium Injection shortage end?
FDA gives no end date. 4 presentations carry a manufacturer’s own estimate, quoted on this page with its date.
Does FDA list alternatives to Methotrexate Sodium Injection?
No. FDA calls a list of alternatives part of the ‘practice of medicine’. Ask your pharmacist or prescriber.